Just thinking out loud here...
View Larger Map
You could very easily do a bus tour that departs from Springfield, winds up in Denver, and does some very good bio-building for Kathleen Sebelius in between.
Start out in Springfield, and proceed to Sebelius' childhood home in Cincinnati by route of Indianapolis and Dayton. Big media appearances on Sunday AM in Cinncinati, and proceed to St. Louis by that evening, with a quick stop in Evansville or Bloomington, Indiana in between. Travel to Kansas City overnight, begin your Monday with an AM event there, and then cross the state line into Kansas and proceed to the state capital in Topeka. At that point, after one more presser, Sebelius leaves the trail, Obama takes a quick detour to his mother's home in El Dorado, and then proceeds on to Denver.